No, this isn't April fools or a comedy post, he's really doing it.
It's comical to see him do this and I don't understand his logic here. If Bitcoin doesn't offer any value, how could you use it to sell art? When confronted on the reasoning for why he's responded with the idea that it's still a real, original oil painting and may hold it's value over time. There will be 50 total prints signed by him and the artist, each with a corresponding Ordinal. Looks like it's going to be auctioned off in NYC.
Whether he eventually admits it has value in the future or not, it doesn't really matter and Bitcoin doesn't need him. But if you're going to be against it but use the technology that really means you acknowledge it's worth.
Previous tweet from 2021: